Genetic analysis of chemoresistance in primary murine lymphomas
Abstract
Understanding the basis of chemoresistance is a principal goal of molecular oncology. We have exploited a murine lymphoma model and retroviral gene transfer to rapidly generate a series of spontaneous tumors differing only in a gene of interest, and subsequently studied the impact of the test gene o …
Keywords
experimental
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Cultured
Genes
drug resistance
adaptation
biological
transgenic
neoplasms
tumor cells
clone cells
gene transfer techniques
lymphoma / genetics*
pmid:10973324
doi:10.1038/79542
c a schmitt
c t rosenthal
s w lowe
culture techniques / methods
multiple / genetics*
bcl-2*
proto-oncogene proteins c-myc / biosynthesis
proto-oncogene proteins c-myc / genetics
retroviridae / genetics
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268639
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