Analysis of Wnt gene expression in prostate cancer: mutual inhibition by WNT11 and the androgen receptor
Abstract
The Wnt signaling pathway is aberrantly activated in many tumor types, including those of the prostate, in which beta-catenin accumulates in cell nuclei and acts as a transcriptional coregulator for the androgen receptor. Because activating mutations in the beta-catenin gene are rare in prostate can …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
RNA
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
cell line
Receptors
transcription
disease progression
signal transduction
messenger / analysis
cell division
androgen / physiology*
wnt proteins
beta catenin
prostatic neoplasms / metabolism
prostatic neoplasms / pathology*
metribolone / pharmacology
pmid:15520198
doi:10.1158/0008-5472.can-04-2704
hanneng zhu
michal mazor
robert m kypta
cytoskeletal proteins / physiology
glycoproteins / genetics*
glycoproteins / physiology
trans-activators / physiology
Citation
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268614
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