Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease
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Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease

Nora Bengoa-Vergniory, Elisavet Velentza-Almpani, Ana Maria Silva, Connor Scott, Mariana Vargas-Caballero, Magdalena Sastre, Richard Wade-Martins, Javier Alegre-Abarrategui;Nora Bengoa-Vergniory;Elisavet Velentza-Almpani;Ana Maria Silva;Connor Scott;Mariana Vargas-Caballero;Magdalena Sastre;Richard Wade-Martins;Javier Alegre-Abarrategui;
acta neuropathologica communications 2021 Vol. 9 pp. -
164
alegre-abarrategui2021actatau-proximity

Abstract

Multimerization is a key process in prion-like disorders such as Alzheimer’s disease (AD), since it is a requirement for self-templating tau and beta-amyloid amyloidogenesis. AT8-immunohistochemistry for hyperphosphorylated tau is currently used ...

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DOI:
10.1186/s40478-020-01117-y
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC78449...

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