p21CIP-1/WAF-1 Induction Is Required to Inhibit Prostate Cancer Growth Elicited by Deficient Expression of the Wnt Inhibitor Dickkopf-1 (DKK-1)

p21CIP-1/WAF-1 Induction Is Required to Inhibit Prostate Cancer Growth Elicited by Deficient Expression of the Wnt Inhibitor Dickkopf-1 (DKK-1)

Christopher L. Hall, Honglai Zhang, Shobun Baile, Mats Ljungman, Stuart Kuhstoss, Evan T. Keller;Christopher L. Hall;Honglai Zhang;Shobun Baile;Mats Ljungman;Stuart Kuhstoss;Evan T. Keller;
Cancer research 2010 Vol. 70 pp. 9916-
82
keller2010cancerp21cip-1/waf-1

Abstract

Osteoblastic bone metastases are the most common metastases produced by human prostate cancers (PCa). Deregulated activity of WNT growth factors resulting from overexpression of the WNT inhibitor DKK-1 is known to contribute to formation of the osteoblastic ...

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