Evolution of cardiac calcium waves from stochastic calcium sparks
Abstract
We present a model that provides a unified framework for studying Ca2+ sparks and Ca2+ waves in cardiac cells. The model is novel in combining 1) use of large currents (approximately 20 pA) through the Ca2+ release units (CRUs) of the sarcoplasmic reticulum (SR); 2) stochastic Ca2+ release (or firin …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
u.s. gov't
P.H.S.
linear models
in vitro techniques
kinetics
stochastic processes
myocardium / cytology
buffers
Biophysics
biophysical phenomena
pmid:11159386
pmc1301217
doi:10.1016/s0006-3495(01)75998-x
l t izu
w g wier
c w balke
calcium signaling / physiology*
cardiovascular*
myocardium / metabolism*
nonlinear dynamics
sarcoplasmic reticulum / metabolism
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268439
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