Bilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland
Abstract
The unilateral corneal nerve severing resulted in activation of the immune cells on the ocular surface and dysregulated lacrimal secretion bilaterally through the bidirectional neuronal signals. It suggests that the unilateral corneal nerve damage may alter immune homeostasis and mechanistically par …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
Inbred BALB C
tears / physiology
enzyme-linked immunosorbent assay
t-lymphocytes
flow cytometry
dendritic cells / metabolism
conjunctiva / metabolism
mee kum kim
lymph nodes / metabolism
pmid:30703211
doi:10.1167/iovs.18-26051
hyo kyung lee
kyoung woo kim
cd4-positive t-lymphocytes / physiology
cd8-positive t-lymphocytes / physiology
coloring agents / metabolism
cornea / innervation*
cornea / metabolism
cranial nerve diseases / etiology*
cranial nerve diseases / immunology
dry eye syndromes / etiology*
dry eye syndromes / immunology
lacrimal apparatus / innervation*
lissamine green dyes / metabolism
ophthalmic nerve / injuries*
regulatory / physiology
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268158
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