Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat
Abstract
Mutations in the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in severely compromised immune system. To identify the causative gene, we utilized modern tools and techniques of positional cloning. Specifically, spanning the region in which the n …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
Inbred C57BL
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
female
male
amino acid sequence
P.H.S.
Rats
DNA
Base Sequence
Molecular Sequence Data
mutation
Crosses
DNA-Binding Proteins / genetics*
transcription
transcription factors / genetics*
nude
chromosome mapping
e s lander
pmid:7490093
doi:10.1006/geno.1995.1187
j a segre
j l nemhauser
complementary / analysis
forkhead transcription factors
inbred akr
restriction mapping
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268099
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