Killing activity of neutrophils is mediated through activation of proteases by K+ flux
Abstract
According to the hitherto accepted view, neutrophils kill ingested microorganisms by subjecting them to high concentrations of highly toxic reactive oxygen species (ROS) and bringing about myeloperoxidase-catalysed halogenation. We show here that this simple scheme, which for many years has served a …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
superoxides / metabolism
candidiasis / immunology
immunologic*
cytotoxicity
neutrophils / immunology*
staphylococcal infections / immunology
electrophysiology
enzyme activation
pmid:11907569
doi:10.1038/416291a
emer p reeves
hui lu
anthony w segal
oxygen / metabolism
peroxidase / deficiency
peroxidase / metabolism*
phagosomes / physiology
potassium / metabolism*
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268001
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