Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD
Abstract
Nondemented individuals exhibit a slow rate of whole-brain atrophy from early in adulthood with white-matter loss beginning in middle age; in older adults, the onset of dementia of the Alzheimer type is associated with a markedly accelerated atrophy rate.
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
adult
female
male
N.I.H.
Extramural
age factors
adolescent
aged
middle aged
P.H.S.
80 and over
regression analysis
reference values
brain / pathology*
longitudinal studies
disease progression
brain / physiopathology
aging / pathology*
alzheimer disease / physiopathology
brain mapping
pmid:15781822
doi:10.1212/01.wnl.0000154530.72969.11
a f fotenos
a z snyder
r l buckner
alzheimer disease / diagnosis*
atrophy / diagnosis*
atrophy / physiopathology
magnetic resonance imaging / standards
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267992
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