Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
Abstract
Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell lines is normally accompanied by loss of the p53 or p19(ARF) tumor suppressors, which act in a common biochemical pathway. myc rapidly activates ARF and p53 gene expression in primary MEFs and triggers replicative …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
gene expression
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
u.s. gov't
P.H.S.
cell line
Genes
mutation
biological
proteins / genetics*
apoptosis / genetics*
signal transduction
gene deletion
pmid:9694806
PMC317045
doi:10.1101/gad.12.15.2424
F Zindy
C M Eischen
M F Roussel
Cell Division / genetics
Tumor Suppressor
myc*
p53*
Tumor Suppressor Protein p14ARF
Citation
ID:
267949
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