A human prostatic epithelial model of hormonal carcinogenesis
Abstract
The effects of stromal and hormonal environment on the immortalized but nontumorigenic human prostatic epithelial cell line BPH-1 were investigated in an in vivo model. BPH-1 cells were recombined with rat urogenital sinus mesenchyme (UGM), and the tissue recombinants were grafted to the renal capsu …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
female
male
P.H.S.
Rats
Antigens
cell line
nude
testosterone / toxicity*
cell division / drug effects
cell transformation
Orchiectomy
epithelial cells / pathology
prostatic neoplasms / pathology
pmid:11507055
y wang
d sudilovsky
s w hayward
polyomavirus transforming / physiology
apoptosis / physiology
neoplastic / drug effects*
neoplastic / pathology
estradiol / toxicity*
mesoderm / cytology
mesoderm / physiology
prostatic neoplasms / chemically induced*
subrenal capsule assay
urogenital system / cytology
urogenital system / embryology
urogenital system / physiology
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267896
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