A polymorphic DNA marker genetically linked to Huntington's disease
Abstract
Family studies show that the Huntington's disease gene is linked to a polymorphic DNA marker that maps to human chromosome 4. The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder.
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Molecular
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
female
male
P.H.S.
human
Polymorphism
chromosome mapping
chromosomes
cloning
pedigree
genetic linkage
pmid:6316146
doi:10.1038/306234a0
j f gusella
n s wexler
a y sakaguchi
4-5*
dna restriction enzymes
huntington disease / diagnosis
huntington disease / genetics*
Citation
ID:
267876
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