research support non-u.s. gov't Clinical Trial Phase III Randomized Controlled Trial Multicenter Study initials='g' affs=[] is_editor=false suffix=none equal_contrib=false) initials='jp' initials='j' initials='a' initials='h' initials='b' initials='n' initials='w' author(firstnames='patrick' initials='p' initials='l' initials='k' initials='d' initials='s' initials='m' initials='f' initials='c' author(firstnames='david' initials='i' author(firstnames='paul' author(firstnames='maria' initials='r' initials='e' initials='v' author(firstnames='richard' initials='t' suffix='jr' pmid:24725239 doi:10.1056/nejmoa1402454 nezam afdhal stefan zeuzem collabauthor(name='ion-1 investigators' investigators=[author(firstnames='marc' lastname='bourlière' author(firstnames='jean-pierre' lastname='bronowicki' author(firstnames='christophe' lastname='hézode' lastname='marcellin' author(firstnames='vlad' lastname='ratziu' author(firstnames='lawrence' lastname='serfaty' lastname='zarski' author(firstnames='thomas' lastname='berg' author(firstnames='peter' lastname='buggisch' lastname='galle' author(firstnames='guido' lastname='gerken' author(firstnames='tobias' lastname='goeser' author(firstnames='ansgar' lastname='lohse' author(firstnames='stefan' lastname='mauss' author(firstnames='robert' lastname='thimme' author(firstnames='hans' lastname='wedemeyer' lastname='zeuzem' author(firstnames='alfredo' lastname='alberti' author(firstnames='pietro' lastname='andreone' author(firstnames='mario' lastname='angelico' author(firstnames='massimo' lastname='colombo' author(firstnames='antonio' lastname='craxì' author(firstnames='alessandra' lastname='mangia' lastname='puoti' lastname='rizzetto' author(firstnames='maribel' lastname='rodriguez-torres' author(firstnames='raúl' lastname='andrade' lastname='buti' author(firstnames='javier' lastname='crespo' author(firstnames='xavier' lastname='forns' initials='x' lastname='garcía-samaniego' author(firstnames='manuel' lastname='romero-gomez' author(firstnames='kosh' lastname='agarwal' author(firstnames='ashley' lastname='brown' author(firstnames='matthew' lastname='cramp' author(firstnames='geoffrey' lastname='dusheiko' author(firstnames='graham' lastname='foster' lastname='mutimer' author(firstnames='andrew' lastname='ustianowski' author(firstnames='nezam' lastname='afdhal' author(firstnames='christopher' lastname='albers' author(firstnames='sanjeev' lastname='arora' author(firstnames='kimberly' lastname='beavers' author(firstnames='michael' lastname='bennett' lastname='bernstein' author(firstnames='norbert' lastname='bräu' lastname='chojkier' author(firstnames='raymond' lastname='chung' author(firstnames='james' lastname='cooper' author(firstnames='mitchell' lastname='davis' author(firstnames='adrian' lastname='di bisceglie' author(firstnames='robin' lastname='dretler' lastname='elion' author(firstnames='gregory' lastname='everson' author(firstnames='steven' lastname='flamm' author(firstnames='bradley' lastname='freilich' lastname='fried' author(firstnames='joseph' lastname='galati' author(firstnames='reem' lastname='ghalib' author(firstnames='norman' lastname='gitlin' author(firstnames='stuart' lastname='gordon' author(firstnames='steven-huy' lastname='han' initials='sh' author(firstnames='trevor' lastname='hawkins' lastname='herring' author(firstnames='federico' lastname='hinestrosa' author(firstnames='ira' lastname='jacobson' author(firstnames='lennox' lastname='jeffers' author(firstnames='kris' lastname='kowdley' author(firstnames='marcelo' lastname='kugelmas' lastname='kwo' author(firstnames='eric' lastname='lawitz' author(firstnames='william' lastname='lee' author(firstnames='timothy' lastname='morgan' author(firstnames='ronald' lastname='nahass' lastname='nelson'