Senescence of human fibroblasts induced by oncogenic Raf

Senescence of human fibroblasts induced by oncogenic Raf

Jiyue Zhu, Douglas Woods, Martin McMahon, J. Michael Bishop;Jiyue Zhu;Douglas Woods;Martin McMahon;J. Michael Bishop;
genes & development 1998 Vol. 12 pp. 2997-
81
bishop1998genessenescence

Abstract

The oncogenes RAS and RAF came to view as agents of neoplastic transformation. However, in normal cells, these genes can have effects that run counter to oncogenic transformation, such as arrest of the cell division cycle, induction of cell differentiation, ...

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