Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes
Abstract
Our results indicate that chloroquine-mediated inhibition of TNF-alpha, IL-1beta and IL-6 synthesis occurs through different modes in lipopolysaccharide-stimulated human monocytes/macrophages: it blocks the conversion of cell-associated TNF-alpha precursor to mature soluble protein, whereas it reduc …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Cells
Cultured
Messenger / genetics
gene expression regulation / drug effects
dose-response relationship
drug
antirheumatic agents / pharmacology*
tumor cells
macrophages / drug effects
cytokines / genetics
lipopolysaccharides / immunology
cytokines / biosynthesis*
macrophages / immunology
interleukin-1 / biosynthesis
tumor necrosis factor-alpha / biosynthesis
tumor necrosis factor-alpha / genetics
pmid:16418198
doi:10.1093/rheumatology/kei282
c-h jang
j-h choi
d-m jue
chloroquine / pharmacology*
interleukin-1 / genetics
interleukin-6 / biosynthesis
interleukin-6 / genetics
monocytes / drug effects*
monocytes / immunology
reverse transcriptase polymerase chain reaction / methods
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267754
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