Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani
Abstract
Infection with the protozoan Leishmania donovani can cause serious visceral disease or subclinical infection in humans. To better understand the pathogenesis of this dichotomy, we have investigated the host cellular immune response to cutaneous or visceral infection in a murine model. Mice infected …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
RNA
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
non-p.h.s.
male
Comparative Study
Cells
Cultured
Antigens
polymerase chain reaction
Inbred BALB C
messenger / metabolism
spleen / metabolism
cricetinae
spleen / immunology
skin / immunology
dna primers / genetics
interleukin-10 / metabolism
lymph nodes / immunology
spleen / cytology
pmid:9423834
pmc107853
doi:10.1128/iai.66.1.18-27.1998
p c melby
y z yang
w zhao
protozoan / immunology
interferon-gamma / metabolism*
interleukin-12 / metabolism
interleukin-4 / metabolism
interleukins / metabolism*
leishmania donovani / immunology*
leishmaniasis
cutaneous / immunology*
visceral / immunology*
lymph nodes / metabolism
nitric oxide synthase / metabolism
skin / metabolism
th1 cells / immunology*
th1 cells / metabolism
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Citation
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267742
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