Twist is a potential oncogene that inhibits apoptosis
Abstract
Oncogene activation increases susceptibility to apoptosis. Thus, tumorigenesis must depend, in part, on compensating mutations that protect from programmed cell death. A functional screen for cDNAs that could counteract the proapoptotic effects of the myc oncogene identified two related bHLH family …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
P.H.S.
Rats
cell line
Genes
Transcription Factors / metabolism*
transcription factors / genetics
cell transformation
neoplastic
cell division
p53
gene deletion
fibroblasts
apoptosis*
ras
nuclear proteins*
pmid:10485844
pmc317004
doi:10.1101/gad.13.17.2207
r maestro
a p dei tos
g j hannon
myc
helix-loop-helix motifs
oncogenes*
repressor proteins*
rhabdomyosarcoma / genetics
tumor suppressor protein p53 / metabolism
twist-related protein 1
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267574
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