Exploring the specificity of the PI3K family inhibitor LY294002
Abstract
The PI3Ks (phosphatidylinositol 3-kinases) regulate cellular signalling networks that are involved in processes linked to the survival, growth, proliferation, metabolism and specialized differentiated functions of cells. The subversion of this network is common in cancer and has also been linked to …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
Animal
Cells
Cultured
cell line
culture media
kinetics
signal transduction / drug effects
enzyme inhibitors / pharmacology*
cell survival / drug effects
proteins / genetics
pmid:17302559
pmc1868829
doi:10.1042/bj20061489
severine i gharbi
marketa j zvelebil
michael d waterfield
chromones / pharmacology*
morpholines / pharmacology*
proteasome endopeptidase complex
proteins / antagonists & inhibitors*
proteins / chemical synthesis
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267549
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