Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome
Abstract
We present evidence that transcriptional activation of the human interferon-beta (IFN beta) gene requires the assembly of a higher order transcription enhancer complex (enhanceosome). This multicomponent complex includes at least three distinct transcription factors and the high mobility group prote …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Drosophila
gene expression regulation
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
enhancer elements
sensitivity and specificity
Promoter Regions
transcription factors / metabolism
transfection
transcription factors / genetics
viral / genetics
genetic / genetics*
pmid:8548797
doi:10.1016/0092-8674(95)90136-1
d thanos
t maniatis
binding sites / physiology
hela cells / physiology
high mobility group proteins / genetics
interferon-beta / genetics*
genetic / genetics
y chromosome / genetics
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267488
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