Therapeutic drug monitoring of amikacin in septic patients
Abstract
TDM resulted in adjustment of AMK therapy in most of our septic patients. Early achievement of an optimal Cpeak/MIC ratio may have an impact on clinical and microbiological responses, but not on outcome. In patients with impaired renal function prior to treatment, AMK therapy may be associated with …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
adult
female
male
aged
middle aged
sepsis / drug therapy*
dose-response relationship
drug
anti-bacterial agents / therapeutic use*
amikacin / therapeutic use*
anti-bacterial agents / blood
pmid:23886243
pmc4057344
doi:10.1186/cc12844
wieslawa duszynska
fabio silvio taccone
andrzej kübler
amikacin / blood
critical illness / therapy*
drug monitoring / methods*
metabolic clearance rate / physiology
sepsis / blood
sepsis / diagnosis
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267481
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