Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism
Abstract
There are major sex differences in insulin sensitivity in adipose tissue, particularly in the intra-abdominal depot, that are regulated by physiological levels of sex steroids. The increased sensitivity to insulin and lipogenesis observed in adipocytes from females may account for their lower level …
Keywords
abdomen
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
RNA
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
N.I.H.
Extramural
Adipocytes / physiology*
adipose tissue / physiology*
Adipocytes / cytology
Glucose / metabolism*
Messenger / genetics
glucose tolerance test
insulin / metabolism
adipose tissue / cytology
sex characteristics*
insulin / pharmacology
estradiol / pharmacology
Orchiectomy
dihydrotestosterone / pharmacology
pmid:19136652
pmc2661589
doi:10.2337/db08-1054
yazmin macotela
jeremie boucher
c ronald kahn
glucose transport proteins
facilitative / genetics
insulin / physiology
lipids / physiology
ovary / cytology
ovary / physiology
skin physiological phenomena
testis / cytology
testis / physiology
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267375
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