Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries
Abstract
The aim of this study was to examine the hypothesis that hypersecretion of ovarian androgens in polycystic ovary syndrome results from an intrinsic abnormality of androgen biosynthesis by thecal cells. Steroid accumulation by human thecal cells from normal and polycystic ovaries (PCO-theca) was exam …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
adult
female
Cells
Cultured
Polycystic Ovary Syndrome / metabolism*
reference values
dose-response relationship
drug
s franks
gonadal steroid hormones / biosynthesis
polycystic ovary syndrome / pathology
androstenedione / metabolism*
pmid:7962289
doi:10.1210/jcem.79.4.7962289
c gilling-smith
d s willis
cell separation
luteinizing hormone / pharmacology
theca cells / metabolism*
Citation
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267364
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