Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone
Abstract
The tendency of prostate cancer to produce osteoblastic bone metastases suggests that cancer cells and osteoblasts interact in ways that contribute to cancer progression. To identify factors that mediate these interactions, we compared gene expression patterns between two bone-derived prostate cance …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
male
N.I.H.
Extramural
cell line
phenotype
signal transduction
wnt proteins / metabolism*
bone neoplasms / metabolism
bone neoplasms / secondary*
pmid:17700537
doi:10.1038/sj.onc.1210694
z g li
j yang
n m navone
intercellular signaling peptides and proteins / metabolism
ldl-receptor related proteins / metabolism*
low density lipoprotein receptor-related protein-5
osteoblasts / metabolism
osteolysis
prostatic neoplasms / metabolism*
prostatic neoplasms / pathology
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267345
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