Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat
Abstract
Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived spec …
Keywords
diet
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Rats
liver / enzymology
aging / pathology
pmid:26803480
pmc4732021
doi:10.1016/j.redox.2016.01.008
maja dziegelewska
susanne holtze
matthias platzer
aging / blood*
cystathionine beta-synthase / genetics
cystathionine beta-synthase / metabolism*
hydrogen sulfide / blood*
longevity / genetics
methionine / metabolism
mole rats
s-adenosylmethionine / metabolism*
Citation
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267319
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