In vitro efficacy of antibiotics commonly used to treat human plague against intracellular Yersinia pestis
Abstract
Yersinia pestis initiates infection as a facultative intracellular parasite in host macrophages; however, little is known about the efficacy of antibiotics commonly used to treat human plague against intracellular Y. pestis. Intracellular minimal bactericidal concentrations (MBCs) were determined us …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
N.I.H.
Extramural
cell line
microbial sensitivity tests
streptomycin / pharmacology
anti-bacterial agents / pharmacology*
chloramphenicol / pharmacology
ciprofloxacin / pharmacology
gentamicins / pharmacology
yersinia pestis / pathogenicity*
plague / prevention & control
yersinia pestis / drug effects*
plague / drug therapy*
amoxicillin / pharmacology
pmid:21628541
pmc3147644
doi:10.1128/aac.01481-10
jered m wendte
duraisamy ponnusamy
kenneth d clinkenbeard
doxycycline / pharmacology
high-throughput screening assays / methods*
macrophages / microbiology
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267318
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