Evidence That Diet-Induced Hyperleptinemia, but Not Hypothalamic Gliosis, Causes Ghrelin Resistance in NPY/AgRP Neurons of Male Mice

Evidence That Diet-Induced Hyperleptinemia, but Not Hypothalamic Gliosis, Causes Ghrelin Resistance in NPY/AgRP Neurons of Male Mice

Briggs, Dana I.;Lockie, Sarah H.;Benzler, Jonas;Wu, Qunli;Stark, Romana;Reichenbach, Alex;Hoy, Andrew J.;Lemus, Moyra B.;Coleman, Harold A.;Parkington, Helena C.;Tups, Alex;Andrews, Zane B.;
endocrinology 2014 Vol. 155 pp. 2411-2422
142
i.2014endocrinologyevidence

Abstract

High-fat diet (HFD) feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/Agouti-related peptide neurons. In the current study, we investigated the

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