Lipopolysaccharide induces both a primary and a secondary phase of sensitization in the developing rat brain
Abstract
Data indicate that bacterial products in combination with other antenatal or postnatal exposures increase the risk of perinatal brain injury. We have previously shown that administration of lipopolysaccharide (LPS) 4 h before hypoxia-ischemia (HI) increases brain injury in 7-d-old rats. The mechanis …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Brain / drug effects*
newborn
Rats
time factors
brain / pathology*
immunohistochemistry
neurons / pathology
brain / pathology
hypoxia-ischemia
pmid:15879289
doi:10.1203/01.pdr.0000163513.03619.8d
saskia eklind
carina mallard
henrik hagberg
brain injuries / chemically induced
hypoxia
lipopolysaccharides / metabolism
lipopolysaccharides / pharmacology*
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267051
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