Exposure-efficacy Relationships for Vedolizumab Induction Therapy in Patients with Ulcerative Colitis or Crohn's Disease
Abstract
Higher vedolizumab serum concentrations were associated with higher remission rates after induction therapy in patients with moderately to severely active UC or CD. This relationship is affected by several factors, including previous TNFα antagonist use. Prospective studies are needed to assess vedo …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
treatment outcome
adult
female
male
adolescent
aged
middle aged
young adult
80 and over
Randomized Controlled Trial
Antibodies
Monoclonal
Double-Blind Method
Humanized / therapeutic use*
Colitis
Ulcerative / drug therapy*
Gastrointestinal Agents / therapeutic use*
dose-response relationship
drug
crohn disease / drug therapy*
remission induction / methods
feces / chemistry
serum albumin / analysis
pmid:28333288
doi:10.1093/ecco-jcc/jjx021
maria rosario
jonathan l french
irving fox
humanized / administration & dosage
humanized / blood
gastrointestinal agents / administration & dosage
leukocyte l1 antigen complex / analysis
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266889
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