BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
Abstract
In humans, mutations in BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden disease, respectively. The development of polyposis is a common feature of these diseases, suggesting that there is an association between BMP and PTEN pathways. T …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Disease Models
Animal
Receptors
transgenic
stem cells / cytology
signal transduction
pmid:15378062
doi:10.1038/ng1430
xi c he
jiwang zhang
linheng li
adenomatous polyposis coli / etiology
adenomatous polyposis coli / genetics
bone morphogenetic protein receptors
type i
bone morphogenetic proteins / physiology*
cytoskeletal proteins / physiology*
epithelial cells / pathology
intestines / cytology*
mutant strains
pten phosphohydrolase
protein tyrosine phosphatases / physiology
protein-serine-threonine kinases / genetics
protein-serine-threonine kinases / physiology
proto-oncogene proteins / physiology*
proto-oncogene proteins c-akt
growth factor / genetics
growth factor / physiology
trans-activators / physiology*
tumor suppressor proteins / physiology
wnt proteins
beta catenin
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266773
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