Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein
Abstract
Repair of a uracil-guanine base pair in DNA has been reconstituted with the recombinant human proteins uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta and DNA ligase III. The XRCC1 protein, which is known to bind DNA ligase III, is not absolutely required for the reac …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
DNA-Binding Proteins / metabolism*
Base Sequence
blotting
western
dna-binding proteins / isolation & purification
substrate specificity
cell-free system
base composition
recombinant proteins / metabolism
pmid:8978692
pmc452490
y kubota
r a nash
t lindahl
dna glycosylases*
dna polymerase i / isolation & purification
dna polymerase i / metabolism*
dna repair*
dna-(apurinic or apyrimidinic site) lyase
deoxyribonuclease iv (phage t4-induced)
guanine
lyases / metabolism
n-glycosyl hydrolases / metabolism*
recombinant proteins / isolation & purification
uracil
uracil-dna glycosidase
x-ray repair cross complementing protein 1
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Citation
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266704
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