Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
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Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

Emmanuelle Querido, Paola Blanchette, Qin Yan, Takumi Kamura, Megan Morrison, Dominique Boivin, William G. Kaelin, Ronald C. Conaway, Joan Weliky Conaway, Philip E. Branton;Emmanuelle Querido;Paola Blanchette;Qin Yan;Takumi Kamura;Megan Morrison;Dominique Boivin;William G. Kaelin;Ronald C. Conaway;Joan Weliky Conaway;Philip E. Branton;
genes & development 2001 Vol. 15 pp. 3104-
56
branton2001genesdegradation

Abstract

Although MDM2 plays a major role in regulating the stability of the p53 tumor suppressor protein, other poorly understood MDM2-independent pathways also exist. Human adenoviruses have evolved strategies to regulate p53 function and stability to permit ...

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DOI:
10.1101/gad.926401
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC312842...

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