Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity
Abstract
To investigate specific effects of androgens on whole body metabolism, we studied six healthy lean men (mean +/- SEM age, 23.2 +/- 0.5 yr) before and after gonadal steroid suppression with a GnRH analog (Lupron), given twice, 3 weeks apart. Primed infusions of [13C]leucine, indirect calorimetry, iso …
Keywords
biopsy
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
adult
male
isometric contraction
P.H.S.
body mass index
skeletal / physiology*
kinetics
energy metabolism
insulin-like growth factor binding protein 3 / blood
insulin-like growth factor i / metabolism
muscle
proteins / metabolism*
pmid:9626114
doi:10.1210/jcem.83.6.4892
n mauras
v hayes
r j urban
adipose tissue*
amino acids / blood
body composition*
calorimetry
indirect
human growth hormone / blood
leuprolide
skeletal / anatomy & histology
testosterone / deficiency*
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266620
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