Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle
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Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle

Miki Jishage, Keiichi Ito, Chi-Shuen Chu, Xiaoling Wang, Masashi Yamaji, Robert G. Roeder;Miki Jishage;Keiichi Ito;Chi-Shuen Chu;Xiaoling Wang;Masashi Yamaji;Robert G. Roeder;
genes & development 2020 Vol. 34 pp. 767-
133
roeder2020genestranscriptional

Abstract

Liver regeneration and metabolism are highly interconnected. Here, we show that hepatocyte-specific ablation of RNA polymerase II (Pol II)-associated Gdown1 leads to down-regulation of highly expressed genes involved in plasma protein synthesis and metabolism, ...

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DOI:
10.1101/gad.337683.120
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC726314...

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ID: 266532
Ref Key: roeder2020genestranscriptional
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