Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex
Abstract
CHROMATIN structure can affect the transcriptional activity of eukaryotic structural genes by blocking access of sequence-specific activator proteins (activators) to their promoter-binding sites. For example, the DNA-binding domain of the yeast GAL4 protein interacts very poorly with nucleosome core …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
P.H.S.
DNA-Binding Proteins / metabolism*
Transcription Factors / metabolism*
recombinant proteins
hela cells
protein conformation
protein binding
dna / metabolism
saccharomyces cerevisiae / genetics
adenosine triphosphate / metabolism
adenosine triphosphatases
saccharomyces cerevisiae proteins*
pmid:8047169
doi:10.1038/370477a0
h kwon
a n imbalzano
m r green
dna helicases
fungal proteins / metabolism
nuclear proteins*
nucleosomes / chemistry
nucleosomes / metabolism*
trans-activators / metabolism
xenopus
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266515
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