Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone
Abstract
Plasma LH is commonly elevated in women with the polycystic ovary syndrome (PCOS), but the underlying mechanisms are uncertain. We tested the hypothesis that the elevated LH in part reflects a reduced sensitivity of the hypothalamic GnRH pulse generator to suppression by estradiol (E2) and progester …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
adult
female
luteinizing hormone / blood
polycystic ovary syndrome / physiopathology*
P.H.S.
j c marshall
follicle stimulating hormone / blood
dose-response relationship
drug
kinetics
progesterone / blood
periodicity
luteinizing hormone / metabolism
hypothalamus / metabolism*
pmid:9467578
doi:10.1210/jcem.83.2.4604
c l pastor
m l griffin-korf
estradiol / administration & dosage
estradiol / pharmacology*
gonadotropin-releasing hormone / metabolism*
hypothalamus / drug effects*
progesterone / administration & dosage
progesterone / pharmacology*
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266131
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