BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny
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BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

Panagiota A. Sotiropoulou, Andrea E. Karambelas, Maud Debaugnies, Aurelie Candi, Peter Bouwman, Virginie Moers, Tatiana Revenco, Ana Sofia Rocha, Kiyotoshi Sekiguchi, Jos Jonkers, Cedric Blanpain;Panagiota A. Sotiropoulou;Andrea E. Karambelas;Maud Debaugnies;Aurelie Candi;Peter Bouwman;Virginie Moers;Tatiana Revenco;Ana Sofia Rocha;Kiyotoshi Sekiguchi;Jos Jonkers;Cedric Blanpain;
genes & development 2013 Vol. 27 pp. 39-
165
blanpain2013genesbrca1

Abstract

The accurate maintenance of genomic integrity is essential for tissue homeostasis. Deregulation of this process leads to cancer and aging. BRCA1 is a critical mediator of this process. Here, we performed conditional deletion of Brca1 during epidermal ...

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DOI:
10.1101/gad.206573.112
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC355328...

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