Impact of goal-oriented and model-based clinical pharmacokinetic dosing of aminoglycosides on clinical outcome: a cost-effectiveness analysis
van Lent-Evers NA;Mathôt RA;Geus WP;van Hout BA;Vinks AA;;
Therapeutic drug monitoring1999Vol. 21pp. -
269
na1999therapeuticimpact
Abstract
The benefits of a pharmacy-based, active therapeutic drug monitoring (TDM) service (ATM) on outcomes were examined in a prospective study at four hospitals. ATM involved pharmacokinetic dosage optimization at the start of treatment, subsequent Bayesian adaptive control, and frequent patient evaluati …