High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity model
Abstract
Interleukin (IL)-15, is a cytokine that is important for the maintenance of long-lasting, high-avidity T cell response to invading pathogens and has, therefore, been used in vaccine and therapeutic platforms as an adjuvant. In addition to pure protein delivery, plasmids encoding the IL-15 gene have …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
N.I.H.
Extramural
Antibodies
plasmids
viral / blood
vaccines
dose-response relationship
drug
macaca mulatta
hemagglutination inhibition tests
cd8-positive t-lymphocytes / immunology
cell proliferation
cd4-positive t-lymphocytes / immunology
intramural
pmid:19683780
pmc4118595
doi:10.1016/j.virol.2009.07.017
jiangmei yin
anlan dai
jean d boyer
influenza vaccines / genetics
influenza vaccines / immunology*
interferon-gamma / metabolism
interleukin-15 / genetics
interleukin-15 / immunology*
dna / genetics
dna / immunology*
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265981
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