Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

Anders M. Näär, Pierre A. Beaurang, Karen M. Robinson, Jon D. Oliner, Daina Avizonis, Sigrid Scheek, Jörk Zwicker, James T. Kadonaga, Robert Tjian;Anders M. Näär;Pierre A. Beaurang;Karen M. Robinson;Jon D. Oliner;Daina Avizonis;Sigrid Scheek;Jörk Zwicker;James T. Kadonaga;Robert Tjian;
genes & development 1998 Vol. 12 pp. 3020-
158
tjian1998geneschromatin,

Abstract

The promoter selectivity factor Sp1 often cooperates with other enhancer-binding proteins to activate transcription. To study the molecular underpinnings of these regulatory events, we have reconstituted in vitro the synergy observed in vivo between Sp1 ...

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