Bacterial endotoxin sensitizes the immature brain to hypoxic--ischaemic injury
Abstract
Epidemiological studies show a markedly increased risk of cerebral palsy following the combined exposure of infection and birth asphyxia. However, the underlying mechanisms of this increased vulnerability remain unclear. We have examined the effects of a low dose of bacterial endotoxin on hypoxic--i …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Brain / drug effects*
Rats
Receptors
messenger / metabolism
brain / pathology*
wistar
reverse transcriptase polymerase chain reaction
lipopolysaccharides / pharmacology
pmid:11285007
doi:10.1046/j.0953-816x.2001.01474.x
s eklind
c mallard
h hagberg
newborn / physiology*
body temperature / drug effects
brain ischemia / mortality
brain ischemia / pathology*
cerebrovascular circulation / drug effects
drosophila proteins*
endotoxins / pharmacology*
hypoxia / mortality
hypoxia / pathology*
lipopolysaccharide receptors / genetics
membrane glycoproteins / genetics
cell surface / genetics
toll-like receptor 4
toll-like receptors
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265926
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