Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing

Ana Eulalio, Jan Rehwinkel, Mona Stricker, Eric Huntzinger, Schu-Fee Yang, Tobias Doerks, Silke Dorner, Peer Bork, Michael Boutros, Elisa Izaurralde;Ana Eulalio;Jan Rehwinkel;Mona Stricker;Eric Huntzinger;Schu-Fee Yang;Tobias Doerks;Silke Dorner;Peer Bork;Michael Boutros;Elisa Izaurralde;
genes & development 2007 Vol. 21 pp. 2558-
155
izaurralde2007genestarget-specific

Abstract

microRNAs (miRNAs) silence gene expression by suppressing protein production and/or by promoting mRNA decay. To elucidate how silencing is accomplished, we screened an RNA interference library for suppressors of miRNA-mediated regulation in Drosophila ...

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