Relationship between the effect of cyclophosphamide on adjuvant arthritis severity, skin allograft rejection and spleen cell cytotoxic activity in rats
Abstract
Cyclophosphamide, which has a poor immunosuppressive effect on adjuvant arthritis in rats, evokes an aggravating form of the disease when applied at a single low dose before rats' sensitization with complete Freund's adjuvant. However, cyclophosphamide administered by this method of treatment has no …
Keywords
immunity
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
Rats
spleen / drug effects
arthritis
experimental / drug therapy*
inbred strains
pmid:2319832
l marinova-mutafchieva
g altankov
i goranov
arthritis / drug therapy*
cell survival / drug effects*
chromium radioisotopes
cyclophosphamide / pharmacology*
graft rejection / drug effects*
cellular / drug effects
skin transplantation
spleen / cytology
spleen / immunology*
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265903
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