Although the use of polyethylene (PE) pipelines has become increasingly widespread in recent years, few studies have addressed their seismic design and ability to withstand blast waves. In order to establish their seismic capacity, the dynamic response of buried pipelines subjected to blast waves must be explored in depth. Here, we studied the dynamic response of PE pipes situated near an explosive source. Time histories of dynamic strains were measured by conventional strain gauges after simple waterproof treatment, and pipe and ground vibration velocity curves were obtained. Based on the experimental data, the attenuation law of the peak strains under the conditions of different charge masses and blast center distances was analyzed, and the spectrum characteristics of strain, velocity of the pipe, and ground velocity were studied. The results revealed that a large hoop strain on the PE pipes was produced due to the local impact near the explosive source. We found that peak hoop strain (PHS) or peak axial strain (PAS) had a power attenuation relationship with the scaled distance, and this relationship could also be derived by dimensional analysis. The average frequency of strains had the same attenuation form as the charge mass, which was between 10 Hz and 50 Hz. Additionally, the vibration of the pipe showed a low frequency. We also determined that the attenuation of the average frequency of pipe and ground vibration velocity was closely related to the charge mass and the scaled distance. Pipe peak vibration velocity (PPVV), ground peak particle velocity (GPPV), and the peak dynamic strain of pipe were highly positively correlated, which verifies the feasibility of using GPPV to characterize pipeline vibration and strain level. Thus, a blasting criterion of 10% minimum request strength (MRS) for PE pipe was proposed, which means that the additional PHS or PAS of the dangerous point must be less than 10% MRS, and we also propose limiting the safety distance–charge mass for blasts near buried PE pipelines by the criterion. Some results in this paper can serve as the basis for future in-depth theoretical research.