The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes
Abstract
Pancreatic beta cell death is a hallmark of type 1 (T1D) and type 2 (T2D) diabetes, but the molecular mechanisms underlying this aspect of diabetic pathology are poorly understood. Here we report that expression of the microRNA (miR)-200 family is strongly induced in islets of diabetic mice and that …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
gene expression regulation
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
diabetes mellitus
signal transduction
apoptosis / genetics
insulin / metabolism
inbred nod
micrornas / metabolism
pmid:25985365
doi:10.1038/nm.3862
bengt-frederik belgardt
kashan ahmed
markus stoffel
cell survival / genetics
type 2 / genetics*
type 2 / pathology
hsp40 heat-shock proteins / biosynthesis
insulin-secreting cells / metabolism*
insulin-secreting cells / pathology
micrornas / genetics*
x-linked inhibitor of apoptosis protein / biosynthesis
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265758
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