ATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress

ATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress

Jairo Rodriguez, Toshio Tsukiyama;Jairo Rodriguez;Toshio Tsukiyama;
genes & development 2013 Vol. 27 pp. 74-
149
tsukiyama2013genesatr-like

Abstract

Faithful DNA replication is essential for normal cell division and differentiation. In eukaryotic cells, DNA replication takes place on chromatin. This poses the critical question as to how DNA replication can progress through chromatin, which is inhibitory ...

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