ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery.
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ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery.

Zhao, Meihui;Zhang, Yu;Yuan, Shirui;Xu, Xiang;Wu, Ziheng;Wu, Zhenghong;Qi, Xiaole;
Soft matter 2019 Vol. 15 pp. 3655-3658
358
zhao2019atpsoft

Abstract

We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and DOX release when suffering enrich ATP in tumor cells.

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DOI:
10.1039/c9sm00480g

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ID: 26396
Ref Key: zhao2019atpsoft
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10.1039/c9sm00480g
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