Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation
Abstract
Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer a potential solution to improve the stability and efficacy of ON drugs. Combined with nanoparticle encapsulation, delivery at the site of action and gene silencing activity of chemically modified ON drugs can be further enhanced. In the present review, several types of ON drugs, selection of chemical modification, and nanoparticle-based delivery systems to deliver these ON drugs are discussed.
Keywords
Organic Chemistry
Medicine (General)
Computer applications to medicine. Medical informatics
environmental effects of industries and plants
renewable energy sources
environmental sciences
psychiatry
transportation engineering
urbanization. city and country
women. feminism
history of oceania (south seas)
languages and literature of eastern asia, africa, oceania
the family. marriage. woman
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