Clonal dominance patterns of CD8 T cells in relation to disease progression in HIV-infected children
Abstract
CD8 T cells are important mediators of cellular immune responses as evidenced by clonal expansions in the CD8 TCR V beta repertoire during primary HIV infection in adults. This study investigated the CD8 TCR V beta repertoire by complementarity-determining region 3 length analysis using multiplex PC …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
adolescent
Child
Infant
Comparative Study
P.H.S.
preschool
Cells
Cultured
polymerase chain reaction
Receptors
disease progression
cd4 lymphocyte count
hiv infections / immunology*
hiv infections / blood
lymphocyte activation
cd8-positive t-lymphocytes / immunology*
hiv infections / metabolism
s pahwa
pmid:10092830
s than
m kharbanda
cd8-positive t-lymphocytes / metabolism*
clone cells / immunology
clone cells / metabolism
fetal blood / metabolism
immunoglobulin variable region / genetics
antigen
t-cell
alpha-beta / biosynthesis
alpha-beta / genetics
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261927
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