An immune control model for viral replication in the CNS during presymptomatic HIV infection
Abstract
The brain is targeted by human immunodeficiency virus type 1 (HIV-1) during the course of untreated infection, leading to cognitive impairment, neurological damage and HIV encephalitis (HIVE). To study early dynamics of HIV entry into the brain, we examined a unique autopsy series of samples obtaine …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
adult
female
male
N.I.H.
Extramural
amino acid sequence
DNA
Sequence Analysis
Viral / analysis
Base Sequence
Molecular Sequence Data
Polymerase Chain Reaction / methods
proviruses / genetics
hiv-1 / genetics
hiv infections / immunology*
cd8-positive t-lymphocytes / immunology
virus replication*
pmid:16317019
doi:10.1093/brain/awh695
m mccrossan
m marsden
p simmonds
central nervous system / immunology*
central nervous system / virology
hiv envelope protein gp120 / analysis
hiv envelope protein gp120 / genetics
hiv-1 / physiology*
immunohistochemistry / methods
lymphoid tissue / immunology
lymphoid tissue / virology
immunological*
peptide fragments / analysis
peptide fragments / genetics
proviruses / physiology*
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261923
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