Prediction of compound synergism from chemical-genetic interactions by machine learning
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Prediction of compound synergism from chemical-genetic interactions by machine learning

Jan Wildenhain, Michaela Spitzer, Sonam Dolma, David Bellows, Nick Jarvik, Rachel White, Marcia Roy, Emma Griffiths, Gerard D. Wright, Mike Tyers;Jan Wildenhain;Michaela Spitzer;Sonam Dolma;David Bellows;Nick Jarvik;Rachel White;Marcia Roy;Emma Griffiths;Gerard D. Wright;Mike Tyers;
cell systems 2015 Vol. 1 pp. 383-
137
tyers2015cellprediction

Abstract

The structure of genetic interaction networks predicts that, analogous to synthetic lethal interactions between non-essential genes, combinations of compounds with latent activities may exhibit potent synergism. To test this hypothesis, we generated a ...

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DOI:
10.1016/j.cels.2015.12.003
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc599882...

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